Fig. 5.
The ribozyme switch system effectively regulates gene expression and cell fate in primary human TCM cells. (A) CD19 expression levels are elevated in the presence of theo. The populations of cells that are (B) live and CD19+ or (C) apoptotic and CD19+ indicate an increase in live cells and decrease in apoptotic cells in response to theo. Values for the L2bulge9(3×) sample are normalized to those of the inactive ribozyme control cultured at the same theo concentration. Reported values are mean ± SD from triplicate samples. The highest level is set to 100%.