Fig. 3.
Representative panel of tumors injected subcutaneously induced by fibroblasts derived from different zones of the prostate. Histomorphologic analysis of tumors induced by human prostate fibroblasts revealed different morphologic patterns with some variation in tumors induced by different fibroblasts: (a) example of a small glandular growth pattern in the tumor induced by central zone (CZ) fibroblasts; (b) a more solid tumor growth with little stroma with transitional zone (TZ) fibroblasts; and (c) diffuse glandular growth with anaplastic features with peripheral zone (PZ) fibroblasts. Immunohistochemical staining for prostate-specific antigen (PSA) in consecutive sections of a P4-2 tumor. (d) Prostate-specific antigen (PSA) antibody (PSA expression red); (e) staining using isotype-specific immunoglobulin as control.