Figure 3.
Minimal radiation toxicity is observed with fractionated dosing regiments of 2 to 2.5 Gy. Orthotopic xenograft response to irradiation. Animals were randomized to irradiation versus placebo once they reached a tumor volume of approximately 200 mm3. (A) All tested radiation schedules reduced orthotopic tumor volume. Each data point is the analysis of data from four animals. (B) Animal weight changes were minimal (<10% decline) with 1.5- to 2.5-Gy fraction doses of radiation. Each data point consists of tumor analysis of eight animals.