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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Nature. 2003 Jun 15;424(6944):76–81. doi: 10.1038/nature01761

Figure 2.

Figure 2

Normal retinal morphology and presence and central connectivity of melanopsin-expressing RGCs in triple-knockout (Opn4−/− Gnat1−/− Cnga3−/−) mice. a, Retinal cross-sections from Opn4+/− and triple-knockout (KO) mice. Giemsa stain shows the various layers. Both are similar in morphology and thickness to wild type. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; IS, inner segment layer; ONL, outer nuclear layer; OPL, outer plexiform layer; OS, outer segment layer. b, Flat-mount view of a triple-knockout retina stained with X-gal (blue). c–e, Coronal sections of triple-knockout mouse brain showing the normal innervations of the SCN, IGL and OPN by X-gal-labelled axons. Dorsal side is up in each case.