TABLE 1.
Peak Cocaine Plasma Levels as a Function of Route, Cocaine Dose, Sex and Menstrual Cycle Phase*
| Males | Females Combined |
Females Follicular |
Females Luteal |
|
|---|---|---|---|---|
| Smoked Cocaine Levels (ng/ml) | N = 10 | N = 11 | N = 11 | N = 11 |
| 0 mg | 5.8 (± 3.2) | 11.1 (± 2.5) | 12.4 (± 4.5) | 10.1 (± 4.8) |
| 6 mg | 106.9 (± 9.3) | 107.1 (± 8.2) | 104.6 (± 13.9) | 102.2 (± 14.7) |
| 12 mg | 214.5 (± 14.5) | 222.2 (± 11.8) | 211.4 (± 12.5) | 238.7 (± 25.7) |
| 25 | 455.3 (± 39.0) | 455.2 (± 24.9) | 442.4 (± 49.8) | 486.8 (± 37.3) |
| Intranasal Cocaine Levels (ng/ml) | N = 10 | N = 8 | N = 8 | N = 8 |
| 0.06 mg/kg | 36.0 (± 6.4) | 31.1 (± 18.8) | 28.2 (± 29.8) | 44.5 (± 33.5) |
| 0.34 mg/kg | 84.7 (± 8.6) | 71.2 (± 9.1) | 80.7 (± 15.6) | 72.7 (± 19.3) |
| 0.69 mg/kg | 155.4 (± 19.6) | 115.7 (± 8.3) | 114.7 (± 16.0) | 129.7 (± 17.4) |
| 1.37 /kg | 342.4 (± 32.0) | 319.5 (± 55.5) | 284.7 (± 73.7) | 354.3 (± 94.4) |
*
These data were adapted from two previously published studies with repeated doses of smoked cocaine (Evans & Foltin, 2006a) and repeated doses of intranasal cocaine (Collins et al., 2007).