FIG. 3.
Comparative magnitudes and distributions of CD8+ T-lymphocyte responses elicited by i.m.-i.m. and i.n.-i.n. heterologous rAd prime-boost regimens. C57BL/6 mice (n = 4/group) were primed by either the i.m. or i.n. route with 109 VP rAd26-Gag. At week 6 following priming, the mice were boosted by either the i.m. or i.n. route with 109 VP rAd5HVR48-Gag. CD8+ T-lymphocyte responses were evaluated over a 20-week time course in multiple anatomic compartments by Db/AL11 tetramer binding assays. The error bars represent SE.