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. Author manuscript; available in PMC: 2010 Sep 17.
Published in final edited form as: Sci Transl Med. 2010 Mar 17;2(23):23ra19. doi: 10.1126/scitranslmed.3000678

Fig. 4.

Fig. 4

Slit2N reduces permeability and mortality in a CLP model of sepsis. (A and B) Mice were subjected to CLP or sham operation and then given an intravenous injection of EBA. EBA accumulation was measured in the kidney (A) or spleen (B) to assess vascular permeability (n = 5). (C) Robo4+/+ mice were subjected to CLP and treated with Mock or Slit2N, and survival was assessed (Mock-treated, n = 15; Slit2N-treated, n = 14). (D and E) Cytokine (D) and chemokine (E) concentrations in the serum of Mock- or Slit2N-treated CLP mice (n = 6). (F) Robo4AP/AP mice were subjected to CLP and treated with Mock or Slit2N, and survival was assessed (Mock-treated, n = 13; Slit2N-treated, n = 13). Error bars represent SEM. *P < 0.05, **P < 0.01, ****P < 0.001.