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. Author manuscript; available in PMC: 2010 May 20.
Published in final edited form as: Arch Gen Psychiatry. 2006 Jul;63(7):808–816. doi: 10.1001/archpsyc.63.7.808

Figure 2.

Figure 2

Sample images from positron emission tomography with raclopride labeled with radioactive carbon (11C) for genotypes found to differentiate subjects with high vs low dopamine (DA) release. The 2 left columns demonstrate decreases in [11C]raclopride binding (a marker for DA release) with smoking (postbreak scans are decay corrected) for subjects with the 9-allele repeat of the dopamine transporter (DAT) gene, less than 7 repeats (DRD4.7–) for the DRD4 genotype, or the Val/Val genotype of the catechol-O-methyltransferase (COMT) polymorphism. The 2 right columns demonstrate little change in [11C]raclopride binding in subjects with the alternate genotypes. VCD/NAc indicates ventral caudate/nucleus accumbens.