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Peak-calling algorithms for ChIP-seq
| Name of algorithm | Notable features |
|---|---|
| MACS [23] | Uses both a control library and local statistics to minimize bias |
| SICER [14] | Designed for detecting diffusely enriched regions; for example, histone modification |
| PeakSeq [24] | Corrects for reference genome mappability and local statistics |
| SISSRs [25] | High resolution, precise identification of binding-site location |
| F-seq [26] | Uses kernel density estimation |
