Fig. 6.
The effect of TLR4 activation on substrate metabolism is partially due to activation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB). C2C12 cells were treated with either 50 pg/ml (A and B) or 500 ng/ml (C and D) of LPS for 2 h in the presence and absence 20 μM of the IκB kinase (IKK) inhibitor parthenolide. The presence of parthenolide either partially or completely blocked the effects of LPS on glucose oxidation and FA oxidation. Data are expressed as means ± SE. *P < 0.05, control vs. LPS.