Fig. 1.
Effects of JDTic on nicotine-induced hypothermia and antinociception. A single injection of nicotine (2.5 mg/kg, s.c.) induced a significant antinociception in the (a) tail-flick and (b) hot-plate tests, and (c) a decrease in body temperature in mice. a Nicotine-induced spinal antinociception measured using the tail-flick test was dose-dependently blocked by 18-h pretreatment with JDTic. JDTic had no significant effect in the hot-plate or body-temperature tests, and the highest dose used did not produce significant behavioral effects in saline treated mice. Each point represents the mean±SEM of six mice per group. Asterisk denotes p<0.05 vs. the saline and JDTic control groups and vs. nicotine-JDTic 16 mg/kg group for the tail-flick test (a)