Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
SGK1 activation is mediated by mTORC2 in the regulation of ENaC. SGK1 associates with mTORC2 (delineated by dashed oval), which phosphorylates S422 in the HM. HM phosphorylated SGK1 interacts with PDK1,37 which phosphorylates T256 (small red circles represent phosphate groups, and red arrows represent phosphorylation events).
