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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Mater. 2009 Nov 8;8(12):993–999. doi: 10.1038/nmat2569

Figure. 3. Internalization of CP-Dox and delivery of drug to the nucleus.

Figure. 3

Confocal laser scanning microscopy images through C26 cells (blue) that show cellular uptake for free Dox, free CP-Oregon Green, and CP-Dox at 5 mins, 30 mins, and 24 hrs. a-c) Free Dox (red) rapidly localizes to the nucleus at all time points. d-f) CP-Oregon Green (green) internalizes into the cytoplasm with intense punctate staining after 30 mins. g-i) CP-Dox (red) nanoparticles produce intense nuclear staining with drug after 30 mins. (bar = 20 μm).