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The DeADMAn approach. Individual Mtb mutants were used to form three distinct pools, each comprising on an equal quantity of 100–120 mutants. NHPs are exposed to infectious aerosols of each pool, and are either subjected to necropsy 24 hr after infection (input), or euthanized when they develop (28.7±4.5 days) pulmonary TB (output). Mtb CFUs obtained from both groups of animals are then used for DeADMAn, to identify Mtb genes required for survival in primate lungs.
