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. 2010 Apr 1;120(5):1494–1505. doi: 10.1172/JCI38331

Figure 2. Increased glucose uptake and utilization rates in Myc-activated myocardium.

Figure 2

(A) MicroPET imaging on representative NTg and MycER mice with or without (Veh) 4-OHT treatment (n = 4/group). The relative amount of tracer uptake into the mouse heart 1 hour after intraperitoneal injection of 18F-FDG is indicated by the color scale (range, 0–30). The arrows indicate the cardiac field. (B) Representative NMR spectra from Myc-induced mouse heart. Labeled glutamate carbons are highlighted. Light gray lines represent peak integration with NUTS program. (C) Fractional contribution of acetyl-CoA from the substrates to the citric acid cycle after 4-OHT treatment. *P < 0.05, MycER mice versus NTg littermates; n = 3/group.