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. Author manuscript; available in PMC: 2010 Apr 21.
Published in final edited form as: Cancer Cell. 2006 Jul;10(1):51–64. doi: 10.1016/j.ccr.2006.06.001

Figure 7. beclin1 haploinsufficiency promotes epithelial tumorigenesis.

Figure 7

A: Tumor growth kinetics of two beclin1+/+ (W4-2, W4-1) and two beclin1+/− (BCLN34-3, BCLN4-1) iBMK cell lines.

B: Tumor growth kinetics of two beclin1+/+, BCL-2-expressing (WB-10, WB-13) and two beclin1+/−, BCL-2-expressing (BLNB-4, BCLNB-13) iBMK cell lines.

C: Histology of two beclin1+/+, BCL-2 (left) and two beclin1+/−, BCL-2 (right) tumors. One out of eight beclin1+/+, BCL-2 tumors and six out of eight beclin1+/−, BCL-2 tumors showed evidence of necrosis (N). All tumors were between 500 and 1000 mm3 at the time of histological analysis.