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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Int Immunopharmacol. 2009 Feb 1;9(5):528–533. doi: 10.1016/j.intimp.2009.01.027

Table I.

TLR expression and direct function on Tregs (modified from (70))

TLR Expression Effect on Trega References
CD4+CD25−
Teff		 CD4+CD25+
Treg		 Proliferation Suppression
TLR1 + + Yesb graphic file with name nihms-113272-t0004.jpg b (20)
TLR2 + + Yes graphic file with name nihms-113272-t0005.jpg (20, 24, 25, 34, 36)
TLR3 + − (16, 21)
TLR4 + ++ Yes graphic file with name nihms-113272-t0006.jpg (20, 25, 26, 49, 52)
TLR5 + ++ no graphic file with name nihms-113272-t0007.jpg (16, 20-23, 29)
TLR6 + + (20)
TLR7 + ++ (15, 20, 22)
TLR8 + ++ graphic file with name nihms-113272-t0008.jpg (19, 20, 22, 29)
TLR9 + + Yes graphic file with name nihms-113272-t0009.jpg (14, 16, 17, 21, 30)
TLR10 − + (29)
a

The indirect effect of TLR via APC on Treg function is not listed here.

b

Based on the property of Pam3CSK4 recognized by TLR2/TLR1 heterodimeric receptor