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. Author manuscript; available in PMC: 2010 Apr 19.
Published in final edited form as: Cancer Cell. 2008 May;13(5):377–378. doi: 10.1016/j.ccr.2008.04.009

Figure 1. Tenovins Inhibit SIRT1 and SIRT2 function.

Figure 1

The mammalian family of sirtuins consists of seven proteins with a variety of cellular functions. Tenovins specifically inhibit SIRT1 and SIRT2, two specific deacetylases for several downstream substrates including the tumor suppressor p53. Inhibition of SIRT1 and SIRT2 by tenovins at single-digit micromolar concentrations has a significant effect on the acetylation levels of their substrates.