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Whole blood LPS activation assay with TNF-α induction as endpoint. Two separate pools of whole blood from two donors each, A and B, were tested for the effects of torcetrapib (1.0 uM final concentration) on TNF-α induction by LPS as described in Materials and Methods. Results are expressed as mean plasma TNF-α concentration ± SD for torcetrapib treated (circles) versus DMSO control (squares) blood.
