Figure 3.
Homologs found by different search methods. Box plot of the CATH homolog coverage achieved by 86 query domains from different CATH homologous superfamilies under different error criteria for SSEARCH [54], PSI-BLAST [4], COMPASS [19•], DALI [8] and VAST [9]. The upper and lower edges of the boxes are at the 75th and 25th percentile, respectively, with the upper and lower whiskers at the 90th and 10th percentile. The middle line is the median amount of coverage and the circles are the outliers. The fractions of CATH homologs identified at four thresholds are shown: reported E()>0.01 (gray boxes); E()>1 (blue); the first non-homolog according to CATH (red); the first non-topolog (different fold) according to CATH (green).