Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1991 Jun;35(6):1232–1234. doi: 10.1128/aac.35.6.1232

In vitro activities of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae.

S G Franzblau 1
PMCID: PMC284318  PMID: 1929269

Abstract

The in vitro activities of a variety of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae were evaluated with the BACTEC 460 system. At 20 micrograms/ml, gentamicin, kanamycin, tobramycin, streptomycin, and amikacin were inactive. Lincomycin was active at 20 micrograms/ml, and clindamycin was active at 0.31 micrograms/ml. Rifamycin SV, rifabutin, and rifampin were active at 3.1, 3.1 to 12.5, and 200 ng/ml, respectively. The in vitro assay correlates well with the in vivo response of M. leprae to antimicrobial agents, with the exception of the aminoglycosides.

Full text

PDF
1232

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colston M. J., Ellard G. A., Gammon P. T. Drugs for combined therapy: experimental studies on the antileprosy activity of ethionamide and prothionamide, and a general review. Lepr Rev. 1978 Jun;49(2):115–126. doi: 10.5935/0305-7518.19780014. [DOI] [PubMed] [Google Scholar]
  2. Franzblau S. G. Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system. Antimicrob Agents Chemother. 1989 Dec;33(12):2115–2117. doi: 10.1128/aac.33.12.2115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Franzblau S. G., Hastings R. C. In vitro and in vivo activities of macrolides against Mycobacterium leprae. Antimicrob Agents Chemother. 1988 Dec;32(12):1758–1762. doi: 10.1128/aac.32.12.1758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Franzblau S. G., O'Sullivan J. F. Structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro. Antimicrob Agents Chemother. 1988 Oct;32(10):1583–1585. doi: 10.1128/aac.32.10.1583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Franzblau S. G. Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium. J Clin Microbiol. 1988 Jan;26(1):18–21. doi: 10.1128/jcm.26.1.18-21.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Franzblau S. G., White K. E. Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae. Antimicrob Agents Chemother. 1990 Feb;34(2):229–231. doi: 10.1128/aac.34.2.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Franzblau S. G., White K. E., O'Sullivan J. F. Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro. Antimicrob Agents Chemother. 1989 Nov;33(11):2004–2005. doi: 10.1128/aac.33.11.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gelber R. H. Further studies of the killing of M. leprae by aminoglycosides: reduced dosage and frequency of administration. Int J Lepr Other Mycobact Dis. 1987 Mar;55(1):78–82. [PubMed] [Google Scholar]
  9. Gelber R. H., Henika P. R., Gibson J. B. The bactericidal activity of various aminoglycoside antibiotics against Mycobacterium leprae in mice. Lepr Rev. 1984 Dec;55(4):341–347. doi: 10.5935/0305-7518.19840038. [DOI] [PubMed] [Google Scholar]
  10. Grosset J. H., Ji B. H., Guelpa-Lauras C. C., Perani E. G., N'Deli L. N. Clinical trial of pefloxacin and ofloxacin in the treatment of lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1990 Jun;58(2):281–295. [PubMed] [Google Scholar]
  11. Harris E. B., Franzblau S. G., Hastings R. C. Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity. Int J Lepr Other Mycobact Dis. 1988 Dec;56(4):588–591. [PubMed] [Google Scholar]
  12. Hastings R. C., Jacobson R. R. Activity of ansamycin against Mycobacterium leprae in mice. Lancet. 1983 Nov 5;2(8358):1079–1080. doi: 10.1016/s0140-6736(83)91060-7. [DOI] [PubMed] [Google Scholar]
  13. Heifets L. B., Lindholm-Levy P. J., Flory M. A. Bactericidal activity in vitro of various rifamycins against Mycobacterium avium and Mycobacterium tuberculosis. Am Rev Respir Dis. 1990 Mar;141(3):626–630. doi: 10.1164/ajrccm/141.3.626. [DOI] [PubMed] [Google Scholar]
  14. Ji B., Perani E. G., Grosset J. H. Effectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice. Antimicrob Agents Chemother. 1991 Mar;35(3):579–581. doi: 10.1128/aac.35.3.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Maggi N., Pallanza R., Sensi P. New derivatives of rifamycin SV. Antimicrob Agents Chemother (Bethesda) 1965;5:765–769. [PubMed] [Google Scholar]
  16. Ramasesh N., Krahenbuhl J. L., Hastings R. C. In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages. Antimicrob Agents Chemother. 1989 May;33(5):657–662. doi: 10.1128/aac.33.5.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SHEPARD C. C., CHANG Y. T. Effect of several anti-leprosy drugs on multiplication of human leprosy bacilli in footpads of mice. Proc Soc Exp Biol Med. 1962 Mar;109:636–638. doi: 10.3181/00379727-109-27293. [DOI] [PubMed] [Google Scholar]
  18. Sensi P., Maggi N., Füresz S., Maffii G. Chemical modifications and biological properties of rifamycins. Antimicrob Agents Chemother (Bethesda) 1966;6:699–714. [PubMed] [Google Scholar]
  19. Shepard C. C. A survey of the drugs with activity against M. leprae in mice. Int J Lepr Other Mycobact Dis. 1971 Apr-Jun;39(2):340–348. [PubMed] [Google Scholar]
  20. Tsutsumi S., Gidoh M. Studies on the development of novel anti-leprous chemotherapeutics using nude mice with special reference to a new quinolone carboxylic acid, AT-4140. Nihon Rai Gakkai Zasshi. 1989 Oct-Dec;58(4):250–258. doi: 10.5025/hansen1977.58.250. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES