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. Author manuscript; available in PMC: 2011 Feb 25.
Published in final edited form as: Neuron. 2010 Feb 25;65(4):445–459. doi: 10.1016/j.neuron.2010.01.016

Figure 3. mGluR reverses cocaine-evoked synaptic plasticity.

Figure 3

Excitatory afferents onto dopamine neurons of the VTA are potentiated after cocaine exposure by the insertion of GluR2-lacking AMPARs. This drug-evoked plasticity can be reversed by mGluR-LTD elicited by strong activation of the excitatory afferents.