Table 1.
Characteristics of the islet recipients and their normal control group, and the pancreas-kidney and kidney recipients and their kidney donor control group
| Islet recipients | Normal controls | Pancreas-kidney recipients | Kidney recipients | Kidney donor controls | |
|---|---|---|---|---|---|
| Sex (M/F) | 3/2 | 5/5 | 3/4 | 4/4 | 4/5 |
| Age (yr) | 44 ± 4 | 40 ± 3 | 40 ± 2 | 45 ± 4 | 45 ± 4 |
| BMI (kg/m2) | 21 ± 1 | 24 ± 1 | 23 ± 1 | 23 ± 1 | 24 ± 1 |
| T1D duration (yr) | 34 ± 3 | 31 ± 2 | |||
| Serum creatinine (mg/dl) | 0.9 ± 0.1 | 0.9 ± 0.0 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 |
| eGFR (ml/min per 1.73 m2)a | 96 ± 14 | 91 ± 5 | 64 ± 4 | 61 ± 5 | 59 ± 4 |
| HbA1c (%) | 6.1 ± 0.2b | 5.3 ± 0.1 | 5.0 ± 0.2 | 5.2 ± 0.2 | 5.1 ± 0.1 |
| Fasting glucose (mg/dl) | 100 ± 6b | 80 ± 2 | 85 ± 3 | 82 ± 2 | 84 ± 1 |
| Fasting insulin (μU/ml) | 7.1 ± 0.9 | 5.5 ± 1.1 | 9.5 ± 1.0 | 7.6 ± 0.8 | 7.4 ± 0.6 |
| Fasting C-peptide (ng/ml) | 0.78 ± 0.18 | 1.12 ± 0.18 | 2.26 ± 0.22c | 2.31 ± 0.23c | 1.50 ± 0.09 |
| Tacrolimus (μg/liter)d | 5.9 ± 0.4 | 9.0 ± 0.8 | 6.7 ± 0.5 |
Data are presented as means ± se. T1D, Type 1 diabetes; eGFR, estimated glomerular filtration rate; M, male; F, female. To convert creatinine to μmol/liter, multiply by 88.40; to convert glucose to mmol/liter, multiply by 0.05551; to convert insulin to pmol/liter, multiply by 7.1750; and to convert C-peptide to nmol/liter, multiply by 0.3310.
a
Estimated by the Modification of Diet in Renal Disease equation (Ref. 21).
b
P < 0.01 vs. normal control group.
c
P < 0.01 vs. kidney donor control group.
d
Adjusted for a portal-to-systemic ratio of 1.54 in islet recipients (Ref. 22).