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ROS inhibit inflammasome activation. (A) Active p10 caspase-1 was expressed more strongly in unstimulated monocytes from CGD patients than in those from healthy controls. (B) NALP3 inflammasome stimulus uric acid crystals stimulated IL-1β release in monocytes isolated from CGD patients, but not in those from healthy controls. Data are presented as mean ± SEM of five healthy controls and of three CGD patients.
