. Author manuscript; available in PMC: 2011 May 1.

Published in final edited form as: Cancer Chemother Pharmacol. 2009 Aug 30;65(6):1067–1081. doi: 10.1007/s00280-009-1112-8

Table 4. Combinative effect of BENSpm pretreatment followed by treatment with FdURd, 5-FU, or paclitaxel in Hs578t, T47D, and MCF-10A cells.

Combination index (CI) values for fractional growth inhibitions of 0.50, 0.75, and 0.90 are shown for combination studies with pretreatment with BENSpm for 24 hours followed by 96 hours simultaneous treatment. CI values were determined as described in Materials and Methods. Values are the means ± SD of three experiments. Synergy CI < 1.00; additivity CI = 1.00; antagonism CI > 1.00.

Hs578t cells

	Fractional Growth Inhibition
	0.5	0.75	0.9
FdUrd	0.302 ± 0.046	0.380 ± 0.063	0.370 ± 0.057
5-FU	0.484 ± 0.074	0.454 ± 0.061	0.436 ± 0.044
C-DDP	0.927 ± 0.134	0.908 ± 0.123	0.902 ± 0.205
Paclitaxel	0.741 ± 0.121	0.803 ± 0.154	0.881 ± 0.210
Docetaxel	0.598 ± 0.088	0.558 ± 0.081	0.529 ± 0.091
Vinorelbine	1.158 ± 0.214	1.183 ± 0.134	1.272 ± 0.224


T47D cells

	Fractional Growth Inhibition
	0.5	0.75	0.9
FdUrd	1.407 ± 0.169	1.349 ± 0.227	1.695 ± 0.430
5-FU	1.569 ± 0.170	1.648 ± 0.351	1.623 ± 0.341
C-DDP	1.299 ± 0.286	1.213 ± 0.345	1.510 ± 0.114
Paclitaxel	0.825 ± 0.156	0.886 ± 0.124	0.776 ± 0.046
Docetaxel	1.178 ± 0.245	1.381 ± 0.249	1.659 ± 0.126
Vinorelbine	1.125 ± 0.127	1.297 ± 0.164	1.137 ± 0.097


MCF-10A cells

	Fractional Growth Inhibition
	0.5	0.75	0.9
FdUrd	0.217 ± 0.045	0.234 ± 0.037	0.293 ± 0.047
5-FU	0.957 ± 0.103	0.927 ± 0.123	0.905 ± 0.147
C-DDP	0.416 ± 0.045	0.418 ± 0.058	0.453 ± 0.065
Paclitaxel	0.554 ± 0.074	0.534 ± 0.049	0.523 ± 0.087
Docetaxel	0.173 ± 0.033	0.361 ± 0.037	0.399 ± 0.035
Vinorelbine	0.388 ± 0.057	0.315 ± 0.056	0.273 ± 0.089