TABLE 3.
Summary of Significant Networks in the Nucleus Accumbens-Shell (ACB-shell) and Central Nucleus of the Amygdala (CeA) revealed with Ingenuity® Pathways Analysis that were altered by Binge-like Ethanol (EtOH) Drinking of P rats
| Region/network | Increased expression-EtOH | Decreased expression-EtOH |
|---|---|---|
| ACB-shell | ||
| Network 1: transcription | 24 genes; Aldoa, Apbb1, Atp1b1, Atp6voc, Crip2, Csnk1g, Ef2b2, Ef2b5, Egfr, Git1, H3f3b, Jmjd6, Map1b, Myh7, Ntrk3, Pick1, Pqbp1, Psmc4, Psmd9, Smarca4, Snd1, Syn2, Thap7, Uqcrc1 | 5 genes; Irf9, Mc4r, Ptprz1, Sh3kbp1, Smc4 |
| Network 2: apoptosis, THR activation, Wnt/beta-catenin signaling | 20 genes; Aip, Akt, Apoe, Axin2, Bsg, Cdc37, Cndl1, Eno1, Fdps, Myh6, Nrgn, Polr2f, Psma3, Psmb10, Psmb8, Tcf4, Thra, Thrb, Tnnc1, Ubtf | 6 genes; Acac, Acin1, Ncoa2, Ncstn, Sulf1, Usp18 |
| Network 3; glucocorticoid receptor signaling; NFKB signaling | 16 genes; Akt1, Anp32a, Atp5j, Basp1, Ctsz, Eif2c2, Ensa, Fabp3, Hras, Nucb1, Phb, Rplp1, Rps10, Stub1, Tcp1, Trex1 | 6 genes; Bmp2, Cybb, Nid1, Ptgs1, Stc1, Trpv1 |
| Network 4; Long Term Potentiation (LTP); Ca+2 signaling | 17 genes; Akap9, Basp1, Cacna1h, Calm1, Calm3, Camk2g, Camk2, Ece1, Fbxo2, Gria1, Grin1, Myo5a, Nrxn1, Scf, Skp1, Snta1, Vwf | 4 genes; F8, Gcnt1, Wipf1, Zfp36l1 |
| Network 5; cell death | 11 genes; Cyb5r3, Fhit, Hdac4, Maea, Mif, Mt3, Psmc3ip, Ras, Rnd3, Serpina1, Tiam1 | 8 genes; Hhex, Kdr, Nmnat1, Pias3, Pld, Pld1, Shc1, Tek |
| CeA | ||
| Network 1; transcription | 18 genes; Acvr2a, Ank3, Araf, Arf5, Cdc1, Cdk7, Chd4, Crkrs, Ctr9, Fus, Gda, Khsrp, Mll, Naplll, Nfil3, Olf3, Smad1, Vapb | 8 genes; Ca4, Cznx, Gusb, Ier2, Insr, Mrps9, Msll, Snapin |