Fig. 3.
Abridged Ingenuity® Pathways Analysis of effects of ethanol drinking in the central nucleus of the amygdala of P rats showing increased expression of genes in glutamate signaling pathways and alterations in gene expression in related pathways. Red indicates increased expression, green indicates decreased expression, and clear symbol indicates genes that were not identified as differentially expressed, but were linked to multiple genes that had changed significantly. Abbreviations: 14-3-3 – tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; Ampar – AMPA receptors; C1qbp – complement component 1, q subcomponent binding protein; Cybb – cytochrome b-245, beta polypeptide; Eif2s2 – eukaryotic translation initiation factor 2, subunit 2 (beta); Gabar-a – GABA receptor associated protein; Gabra1 – gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; Gabrg1 – gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1; Gabrg2 – gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; Gnai2 – guanine nucleotide binding protein (G protein), alpha inhibiting 1; Gri – glutamate receptor, ionotropic; Gria1, 2, 3 – glutamate receptor ionotropic AMPA 1 (alpha 1, 2, 3); Grik2 – glutamate receptor, ionotropic, kainate 2 (beta 2); Grik5 – glutamate receptor, ionotropic, kainate 5 (gamma 2); Mek1/2 – mitogen-activated protein kinase kinase ½; Mgmt – O-6-methylguanine-DNA methyltransferase; Nmnat1 – nicotinamide nucleotide adenyltransferase 1; Nsf –N-ethylmaleimide sensitive fusion protein; P2ry1 – purinergic receptor P2Y, G-protein coupled 1; Pkca – protein kinase C alpha; Rgs2 – regulator of G protein signaling 2; Rgs 7 – regulator of G protein signaling 7; Stx3 – syntaxin 3. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)