Table 1.
Representative neurophisiological and neurophatological conditions involving IL-18
| Condition | Species | Citation |
|---|---|---|
| Behavior | ||
| Sleep | Rat/Rabbit | [72] |
| Fever | Mouse | [73,162] |
| Feeding | Mouse | [10,11] |
| Learning and memory | Mouse | [77] |
| Rat | [48,74,75] | |
| Human | [108,111,163] | |
| Stress and HPA axis | ||
| Rat | [56,57,81] | |
| Rat/Mouse | [62] | |
| Holstein cattle | [80] | |
| Pig | [54,55] | |
| Human | [136] | |
| Neuroinflammation | ||
| Brain injury | ||
| Hypoxia-ischemia | Mouse | [67,84,164-167] |
| Rat | [67,168] | |
| Thromboembolic stroke | Mouse | [83] |
| Spinal cord injury | Rat | [87] |
| Focal brain ischemia | Rat | [86] |
| Stroke | Mouse | [59,85] |
| Human | [169] | |
| Nerve injury | Rat | [47] |
| Viral infection | Chicken | [170] |
| Human | [59,171] | |
| Autoimmune neurodegenerative disease | ||
| Multiple Sclerosis | Human | [95-99,101] |
| EAE | Mouse | [91,93,100] |
| Rat | [89,90,92,94] | |
| Neurodegenerative disease | ||
| Alzheimer's disease | Human | [50,106-109,111-114] |
| Parkinson's disease | Mouse | [117] |
| Neuropsychiatric disorders | ||
| Depression | Rat | [133] |
| Human | [136,137,139] | |
| Schizophrenia | Human | [134,135] |
| Other central actions | ||
| Excitotoxic damage | ||
| Ataxia | Mouse | [53] |
| Neurodegeneration | Mouse | [150] |
| Glioma | Rat | [156,157] |
| Mouse | [152-155] | |