Table 2.
Cooperating genetic changes in leukemic mice belonging to groups 1 and 2
| Group/tumor ID | Genotype | Stem cell* | Proliferation* | Tumor suppressor* | Novel | Others |
|---|---|---|---|---|---|---|
| Group 1: myeloid leukemia | ||||||
| 696 | Runx1−/− | Gfi1/Evi5 (c) | c-Myc (c) | |||
| 807 | Runx1−/− | Ncoa2‡ | Ing4 | Rbm34 | ||
| 966 | Runx1−/− | Evi1 (c) | IL6st | |||
| 714 | Runx1−/− | Gfi1/Evi5 (c) | Cyclin D3 (c), Cyclin D2 (c) | Dab2‡ | Lfng, Swap70 | |
| 708 | Runx1−/− | Evi1 (c) | Pik3cd | Mapk9 (Jnk) | Slis7 (c) | Tmem23‡ |
| Group 2: biphenotypic leukemia | ||||||
| 691† | Runx1−/− | |||||
| 813 | Runx1−/− | Gfi1/Evi5 (c)‡ | Slis6 (c) | Arhgap25 | ||
| 775 | Runx1−/− | c-Myc (c) | Gimap7, Ak1 | |||
| 770 | Runx1−/− | Cyclin D3 (c), Sema4d | Gadd45 | Slis7 (c) | Cspg4, mSin3a | |
| 641 | Runx1−/− | Cyclin D3 (c), Cyclin D2 (c) | Stag1§ | Slis8 (c) | Ang 2 | |
| 819 | Runx1−/− | Gfi1/Evi5 (c) | Stx4a, Negr1 | |||
| 821 | Runx1−/− | |||||
| 779 | Runx1−/− | c-Myc (c) | Nkd1 | Slis8 (c) | ||
| 982 | Runx1−/− | Gfi1/Evi5 (c) | Stag1§ | Slis6 (c) | Limk2 | |
| 972 | Runx1−/− | Ppfibp1 | ||||
| 969 | Runx1−/− | Gfi1/Evi5 (c), Evi1 (c) | N-myc (c)‡, Cyclin D1 (c) | Mad1l1‡ | Rabggtb | |
| 948 | Runx1−/− | Gfi1/Evi5 (c) | N-myc (c)‡ | Stk16, Mdm4 | ||
| 974 | Runx1−/− | Lmo2‖ | c-Myc (c), Cyclin D3 (c), Lef1 | Ldb1 | ||
| 693 | Runx1+/+ | Tnfrsf191 | Tspan32 | |||
| 690 | Runx1+/+ | Lmo2‖ | Foxp1 | |||
| 663 | Runx1+/+ | Gfi1/Evi5 (c) | Pip5k2a‡ | Ugcg | ||
| Unclassified‡ | ||||||
| 2 | Runx1−/− | Gfi1/Evi5 (c) | N-myc (c)‡, Sept9, Pim2 | |||
| 4 | Runx1−/− | Gfi1/Evi5 (c)‡, Hes1 | IL2 | Slis6 (c) | Birc4 | |
| 998 | Runx1−/− | Gfi1/Evi5 (c) | ||||
| 838 | Runx1−/− | Gfi1/Evi5 (c)‡ |
Table shows the genes near CISs or RISs that may have a role in oncogenesis based on their known or predicted function. (c) indicates CISs identified in this study. Leukemia cases in each group are arranged in ascending order of latency.
*
Known or predicted function.
†
RIS information is not available for this sample.
‡
Genes with retroviral integrations inside the gene.
§
Unclassified leukemia cases, which could belong to group 1 or 2; they showed early onset of disease and no enlargement of thymus/lymph node, and flow cytometric data are not available.
‖
Gene near 2 RISs that cannot be classified as CISs based on definition.