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. Author manuscript; available in PMC: 2010 Mar 2.
Published in final edited form as: Cancer Prev Res (Phila). 2008 Nov;1(6):439–451. doi: 10.1158/1940-6207.CAPR-08-0165

Table 1.

The IC50 of flavokawain A and tumor suppressor gene status in bladder cancer cell lines

Cell lines
RT4 UMUC-3 T24 HT1376 5637 TCCSUP HT1197
Estimated IC50 (µmol/L) 20.8 17.7 16.7 14.7 13.1 10.55 7.9
p53 WT MT/Exon 4 MT/Exon 5 MT/Exon 7 MT/Exon 8 MT/Exon 10 MT/Exon 10
RB − + + − − − −
ARF/p16 HD/HD HD/HD WT/MT WT/WT WT/WT WT/WT WT/WT

NOTE: Retinoblastoma gene status implied from the expression of protein localized to the nucleus (+, presence of nuclear expression; −, absence of nuclear expression). Tumor suppressors p14 (ARF) and p16 (INK4A; p16).

Abbreviations: WT, wild-type; MT, mutant allele; RB, retinoblastoma; HD, homozygous deletion.