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. 2010 Feb 1;9:8. doi: 10.1186/1475-2840-9-8

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Copyright ©2010 Searls et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IP₃R and RyR Protein Distribution Changes with High Glucose Treatment. Immunofluorescence experiments picture the relative location of each IP₃R isoform in the cells grown in medium and high glucose. Few changes were noted in the distribution of IP₃R-1 (A and B). There was a loss in fluorescence in IP₃R-2 (C and D) and IP₃R-3 (E and F) with high glucose treatment are shown. Cells grown in medium glucose conditions displayed primarily cytoplasmic staining of the RyR with perinuclear localization (G). RyR in cells grown in high glucose exhibited strong nuclear localization (H).