Table 1.
Selected serous carcinoma biomarkers in the FT ex-vivo culture secretome. A representative subset of proteins that are secreted by FTE cells in the ex-vivo cultures, and were previously reported to be detectable in ovarian cancer or FT secretions. The incidence of is calculated out of 11 different patients’ samples. Proteins secreted by at least one of two OSE samples analyzed in an identical manner are marked.
| Accession Number | Protein Description | Incidence* | Expressed by OSE |
|---|---|---|---|
| gi|115298678|ref|NP_000055.2| | complement component 3 precursor [Homo sapiens] | 8 | |
| gi|4557871|ref|NP_001054.1| | transferrin [Homo sapiens] | 8 | |
| gi|5032057|ref|NP_005611.1| | S100 calcium binding protein A11 [Homo sapiens] | 7 | |
| gi|22208982|ref|NP_002767.2| | kallikrein-related peptidase 10 preproprotein [Homo sapiens] | 6 | |
| gi|4507509|ref|NP_003245.1| | tissue inhibitor of metalloproteinase 1 precursor [Homo sapiens] | 6 | + |
| gi|83367077|ref|NP_078966.2| | mucin 16 [Homo sapiens] | 6 | |
| gi|4504919|ref|NP_002264.1| | keratin 8 [Homo sapiens] | 5 | |
| gi|62414289|ref|NP_003371.2| | vimentin [Homo sapiens] | 5 | + |
| gi|4505185|ref|NP_002406.1| | macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] | 5 | + |
| gi|4505773|ref|NP_002625.1| | prohibitin [Homo sapiens] | 5 | |
| gi|53988378|ref|NP_005814.2| | mesothelin isoform 1 preproprotein [Homo sapiens] | 5 | |
| gi|4502693|ref|NP_001760.1| | CD9 antigen [Homo sapiens] | 5 | |
| gi|4557485|ref|NP_000087.1| | ceruloplasmin precursor [Homo sapiens] | 4 | |
| gi|56699495|ref|NP_006094.3| | WAP four-disulfide core domain 2 precursor [Homo sapiens] | 4 | |
| gi|48255935|ref|NP_000601.3| | CD44 antigen isoform 1 precursor [Homo sapiens] | 4 | |
| gi|5031701|ref|NP_005851.1| | follistatin-like 3 glycoprotein precursor [Homo sapiens] | 4 | |
| gi|91984773|ref|NP_658985.2| | apolipoprotein A-I binding protein precursor [Homo sapiens] | 3 | |
| gi|67782365|ref|NP_005547.3| | keratin 7 [Homo sapiens] | 3 | |
| gi|5453678|ref|NP_006423.1| | epididymal secretory protein E1 precursor [Homo sapiens] | 3 | |
| gi|21237748|ref|NP_004348.2| | CD151 antigen [Homo sapiens] | 3 | |
| gi|4507065|ref|NP_003055.1| | secretory leukocyte peptidase inhibitor precursor [Homo sapiens] | 3 | |
| gi|4505787|ref|NP_002629.1| | elafin preproprotein [Homo sapiens] | 3 | |
| gi|5453541|ref|NP_006399.1| | anterior gradient 2 homolog [Homo sapiens] | 2 | |
| gi|65301117|ref|NP_002447.4| | mucin 1 isoform 1 precursor [Homo sapiens] | 2 | |
| gi|65507501|ref|NP_001018059.1| | * glycodelin precursor [Homo sapiens] | 2 | |
| gi|4505583 | * progestagen-associated endometrial protein (placental protein 14; pregnancy-associated endometrial tumor-associated calcium signal transducer 1 precursor[Homo sapiens] | 2 | |
| gi|4505059|ref|NP_002345.1| | oviductal glycoprotein 1 precursor [Homo sapiens] | 2 | |
| gi|58386720|ref|NP_002548.3| | * the same protein | 1 |
*
A total of eleven (11) fallopian tube culture secretions were analyzed using liquid chromatography tandem mass spectrometry (MS). This column represent the number of samples (out of 11) in which this particular protein was identified by MS.