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. Author manuscript; available in PMC: 2010 Feb 24.
Published in final edited form as: Mod Pathol. 2009 Nov 6;23(2):187–196. doi: 10.1038/modpathol.2009.157

Figure 2.

Figure 2

Immunohistochemical staining of cortactin in human melanomas. (a and b) Strong staining in invasive melanoma, with an accentuated cell periphery (a) and dot-like (b) distribution. (c–f) Increased expression in metastatic melanomas. The protein is most commonly seen at the cell periphery (c, d and f), with resemblance to membrane ruffles seen in cultured cells. In occasional cases, it is seen as a globule in the cytoplasm (e).