Table 2.
Cohort characteristics
| Site characteristics | Subjects (%) | Sites (%) |
|---|---|---|
| N = 15,022 | N = 165 | |
| Hospital size | ||
| <250 beds | 9.9 | 19.3 |
| 250–500 beds | 42.3 | 39.8 |
| >500 beds | 47.8 | 40.9 |
| Teaching status | ||
| Teaching | 69.2 | 69.3 |
| Non-teaching | 30.8 | 30.7 |
| ICU Type | ||
| Medical | 23.3 | 17.0 |
| Medical/surgical | 71.3 | 78.4 |
| Other | 5.4 | 4.6 |
| Region | ||
| Europe | 31.1 | 41.0 |
| North America | 58.9 | 47.0 |
| South America | 10.0 | 12.0 |
| Patient characteristics | Subjects (%) | Hospital mortality (%) |
|---|---|---|
| All | 100 | 34.8 |
| Source | ||
| ED | 52.4 | 27.6 |
| ICU | 12.8 | 41.3 |
| Ward | 34.8 | 46.8 |
| Site of infection | ||
| Pneumonia | 44.4 | 38.2 |
| UTI | 20.8 | 25.1 |
| Abdominal | 21.1 | 40.8 |
| Meningitis | 1.6 | 23.0 |
| Skin | 5.9 | 28.6 |
| Bone | 1.2 | 31.9 |
| Wound | 3.8 | 32.2 |
| Catheter | 4.1 | 33.9 |
| Endocarditis | 1.1 | 41.0 |
| Device | 1.1 | 42.5 |
| Other infection | 12.7 | 33.1 |
| Baseline acute organ dysfunctions | ||
| Cardiovasculara | 85.6 | 35.4 |
| Pulmonaryb | 30.8 | 41.5 |
| Renab | 39.5 | 40.5 |
| Hepaticb | 10.2 | 45.1 |
| Hematologicb | 25.7 | 45.0 |
| Number of acute organ dysfunctions | ||
| 1 | 41.8 | 27.4 |
| 2 | 32.2 | 34.4 |
| 3 | 17.8 | 43.7 |
| 4 | 6.4 | 52.5 |
| 5 | 1.8 | 63.6 |
| Cardiovascular | ||
| No cardiovascular dysfunction | 13.5 | 31.0 |
| Cardiovascular dysfunction no hypotension | 15.0 | 21.2 |
| Shock | ||
| Lactate >4 only | 5.4 | 29.9 |
| Vasopressors only | 49.5 | 36.7 |
| Lactate >4 and vasopressors | 16.6 | 46.1 |
| Total shock | 71.5 | 38.4 |
aIncludes hypotension regardless of response to fluids and elevated lactate
bPer severe sepsis screening tool, supplemental Fig. 1 online