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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: J Invest Dermatol. 2009 Oct 8;130(3):901–903. doi: 10.1038/jid.2009.312

Figure 1. Amplification of EGFR in SCCs.

Figure 1

a) Array comparative genomic hybridization profile showing amplification of EGFR (arrow) on chromosome 7 in an SCC. b) FISH demonstrating two copies of the control centromeric probe for chromosome 7 (green) and increased copy number of a probe for EGFR (red). Scale bar 10 μm. c and d) Representative case of an SCC with amplification of EGFR and concomitant overexpression of EGFR protein by immunohistochemistry. Lesional (c) and non-lesional skin (d). Scale bar 0.1 mm.