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. Author manuscript; available in PMC: 2011 Mar 3.
Published in final edited form as: J Control Release. 2009 Oct 17;142(2):187–195. doi: 10.1016/j.jconrel.2009.10.013

Figure 7.

Figure 7

Antibody responses in mice after vaccination. (A) Virus-specific total IgG and isotype antibodies after a single vaccination. Influenza virus-specific serum antibody responses were determined at week 4 post-immunization. Antibody levels in 100× diluted serum samples were determined by ELISA using inactivated virus as a coating antigen and presented as optical densities (OD at 450 nm). (B) At week 4 after a single vaccination, hemagglutination inhibition (HAI) titers in sera were determined. Mock = microneedle immunization with coating solution only; MN = microneedle immunization with influenza vaccine formulated in the absence of trehalose; MN+Tre = microneedle immunization with influenza vaccine formulated in the presence of trehalose (15%); IM = intramuscular immunization with liquid influenza vaccine. (n=6 per group)