Table 1.
Gene ontology terms for genes up-regulated in CCL-171 cells by insulin-like growth factor (IGF-I).
| Gene ontology term | Cluster frequency | Gene frequency in background | Corrected P-value |
FDR | False positives |
|---|---|---|---|---|---|
| M phase | 42 out of 325 genes, 12.9% | 67 out of 2133 genes, 3.1% | 1.84E-16 | 0.0% | 0.0 |
| Cell cycle phase | 45 out of 325 genes, 13.8% | 82 out of 2133 genes, 3.8% | 1.46E-14 | 0.0% | 0.0 |
| Cell division | 38 out of 325 genes, 11.7% | 69 out of 2133 genes, 3.2% | 5.07E-12 | 0.0% | 0.0 |
| M phase of mitotic cell cycle | 32 out of 325 genes, 9.8% | 52 out of 2133 genes, 2.4% | 1.06E-11 | 0.0% | 0.0 |
| Cell cycle process | 50 out of 325 genes, 15.4% | 113 out of 2133 genes, 5.3% | 2.13E-11 | 0.0% | 0.0 |
| Nuclear division | 31 out of 325 genes, 9.5% | 51 out of 2133 genes, 2.4% | 4.65E-11 | 0.0% | 0.0 |
| Mitosis | 31 out of 325 genes, 9.5% | 51 out of 2133 genes, 2.4% | 4.65E-11 | 0.0% | 0.0 |
| Cell cycle | 57 out of 325 genes, 17.5% | 143 out of 2133 genes, 6.7% | 7.11E-11 | 0.0% | 0.0 |
| Organelle fission | 31 out of 325 genes, 9.5% | 52 out of 2133 genes, 2.4% | 9.95E-11 | 0.0% | 0.0 |
| Mitotic cell cycle | 39 out of 325 genes, 12.0% | 86 out of 2133 genes, 4.0% | 7.94E-09 | 0.0% | 0.0 |
| Organelle organization | 67 out of 325 genes, 20.6% | 217 out of 2133 genes, 10.2% | 4.21E-07 | 0.0% | 0.0 |
| Cellular component organization | 91 out of 325 genes, 28.0% | 358 out of 2133 genes, 16.8% | 1.78E-05 | 0.0% | 0.0 |
| Microtubule-based process | 21 out of 325 genes, 6.5% | 40 out of 2133 genes, 1.9% | 2.56E-05 | 0.0% | 0.0 |
| Regulation of mitotic cell cycle | 17 out of 325 genes, 5.2% | 31 out of 2133 genes, 1.5% | 2.40E-04 | 0.0% | 0.0 |
| Spindle organization | 10 out of 325 genes, 3.1% | 14 out of 2133 genes, 0.7% | 2.70E-03 | 0.4% | 0.1 |
| Microtubule-based Movement | 10 out of 325 genes, 3.1% | 15 out of 2133 genes, 0.7% | 0.01 | 0.6% | 0.1 |
| Mitotic cell cycle checkpoint | 9 out of 325 genes, 2.8% | 13 out of 2133 genes, 0.6% | 0.01 | 0.6% | 0.1 |
| Regulation of cell cycle | 27 out of 325 genes, 8.3% | 79 out of 2133 genes, 3.7% | 0.01 | 0.6% | 0.1 |
| Biological regulation | 152 out of 325 genes, 46.8% | 785 out of 2133 genes, 36.8% | 0.04 | 0.6% | 0.1 |
| Microtubule cytoskeleton organization | 12 out of 325 genes, 3.7% | 24 out of 2133 genes, 1.1% | 0.05 | 0.7% | 0.1 |
Detailed list of gene ontology terms specifically up-regulated in CCL-171 fibroblasts upon IGF-I stimulation in comparison to background file including all genes deregulated by IGF-I. Bonferroni corrected p values for of the output from GO::Termfinder for process ontology are listed.
FDR, false discovery rate.