Figure 4. Anatomical imaging information.
For simplicity in other figures, imaging biomarkers have been shown as individual curves. However, anatomical variation exists in the time courses within each imaging mode. For example, in FDG-PET, one would expect abnormalities to appear in the following order: precuneus/posterior cingulate, lateral temporal, and frontal lobe much later. Similarly, in structural MRI, one would expect abnormalities to appear in the following order: medial temporal, lateral temporal, and frontal lobe later. FGD=fluorodeoxyglucose.