Table 1.
Candidate genes
| Gene | Isoformsa | miRNA | Sitesb | Function |
|---|---|---|---|---|
| HMGA2 | >1 | let-7 | 7 | Architectural transcription factor; cancer, stem cell biology |
| C12orf28 | 0 | let-7 | 4 | Unknown |
| LIN28B | 1 | let-7 | 5 | Homolog of Lin28, reprogramming of human fibroblasts |
| TRIM71 | 0 | let-7 | 2 | Development |
| IMP-1 | 3 | let-7 | 5 | RNA-binding protein; mRNA stability, translational control, mRNA transport |
| ARID3B | 1 | let-7 | 5 | DNA-binding protein; development, oncogene |
| FIGN | 0 | let-7 | 3 | Development |
| PUNC | 0 | let-7 | 3 | Development |
| SMARCAD1 | 0 | let-7 | 2 | Helicase; chromatin remodeling |
| YOD1 | 1 | let-7 | 4 | Deubiquitinating enzyme |
| BACH1 | 1 | let-7 | 2 | Transcription factor |
| CPEB2 | 1 | let-7 | 3 | RNA-binding protein; development, cell division, senescence, synaptic plasticity |
| IMP-3 | 2 | let-7 | 1 | RNA-binding protein |
| IMP-2 | 2 | let-7 | 2 | RNA-binding protein |
| FGF2 | 3 | miR-15/16 | 5 | Mitogen; development, wound healing, tumor growth |
| PLAG1 | 1 | miR-15/16 | 2 | Zink finger protein; rearranged in pleomorphic adenoma |
| MYB | 1 | miR-15/16 | 2 | Transcription factor; oncogene |
| TACC1 | 0 | miR-15/16 | 2 | Oncogene |
| CCND2 | 2 | miR-15/16 | 3 | Cyclin; oncogene |
| CCND1 | 2 | miR-15/16 | 2 | Cyclin; oncogene |
| DICER1 | 2–3 | miR-103/107 | 6 | miRNA biogenesis |
| RAB10 | 2 | miR-103/107 | 3 | Ras-related GTP-binding protein |
| RUNX1 | 0 | miR-27 | 2 | Subunit of transcription factor; hematopoiesis |
a
0, not expressed in the cell lines and tissues investigated.
b
Listed are the number of sites for the indicated miRNAs.