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. Author manuscript; available in PMC: 2011 Jan 6.
Published in final edited form as: Cell Calcium. 2010 Jan 6;47(1):65. doi: 10.1016/j.ceca.2009.11.006

Figure 8.

Figure 8

Mechanical stimulation induced intercellular Ca2+ wave (ICW) propagation model in submandibular gland cells. A. Mechanical stimulation (MS) directly activates mechanosensitive maxi-anion channels (mAC) to induce ATP release into extracellular medium. B. Ca2+ mobilization mechanisms in a single cell during ICW propagation. (a) ATP binding to P2Y2 receptors in the cell surface activates PLC, which generates IP3. This IP3 activates IP3 receptors in the ER and causes a Ca2+ release. Depletion of Ca2+ stores in the ER further activates SOCC to induce Ca2+ influx from the extracellular medium. Under normal conditions, mitochondria efficiently take up local Ca2+ and this prevents SOCC inactivation. (b) Inhibition of mitochondrial Ca2+ uptake increases the local Ca2+ concentrations, which causes Ca2+-dependent inactivation of SOCC.