Figure 4.
In vivo optical imaging of nude mice bearing A431 tumors using Eaff800. (A) A representative series of whole body images (dorsal view) acquired at different time points after injection of 0.5 nmol of Eaff800. The tumors were indicated with arrows. (B) Clearance of Eaff800 from the tumor and normal tissue. Average signal intensities were quantified using ROIs of equivalent-sized areas from the tumor sites and contralateral sites at indicated time points. Data were presented as mean ± SD of three individual mice. (C) TBR at different time points after probe injection. TBR was calculated by dividing the mean tumor signal by the mean background signal of the contralateral site.