. 2009 Nov 24;102(1):220–226. doi: 10.1038/sj.bjc.6605435

Table 2. Risk of second solid primary cancer after invasive locoregional breast cancer in 5-year survivors (SEER 9 registries: 1973–2005).

		Surgery+radiotherapy			Surgery only
		Observed	Expected		Observed	Expected
Dose groupinga	Cancer site	cases	cases	SIR	cases	cases	SIR	RRb	(95% CI)
High (1+ Gy)	Oesophagus	56	24.98	2.24^*	68	61.58	1.10
	Pleura	2	0.22	9.14^*	0	0.50	0
	Lung	814	673.16	1.21^*	1,387	1582.33	0.88^*
	Bone	13	4.14	3.14^*	17	9.33	1.82^*
	Soft tissuec	56	18.95	2.96^*	48	42.50	1.13
	Sub-total	941	721.50	1.30^*	1520	1697.63	0.90^*	1.45	(1.33–1.58)

Medium (0.5–0.99 Gy)	Stomach	56	54.18	1.02	158	138.36	1.14
	Liver/gall bladder	35	61.90	0.57^*	110	147.33	0.75^*
	Larynx	10	19.35	0.52^*	35	47.27	0.74
	Thyroid	72	62.78	1.15	129	122.43	1.05
	CNS	4	2.76	1.45	8	6.13	1.31
	Sub-total	177	200.98	0.88	440	461.75	0.95	0.89	(0.74–1.06)

Low (<0.5 Gy)	Oral cavity	61	64.74	0.94	147	158.72	0.93
	Salivary gland	16	8.85	1.81^*	24	20.26	1.18
	Colon	364	387.89	0.94	921	975.15	0.94
	Rectum	118	128.31	0.92	285	320.40	0.89
	Pancreas	103	115.47	0.89	268	281.74	0.95
	Melanoma of the skin	125	118.12	1.06	249	248.37	1.00
	Cervix uteri	30	52.46	0.57^*	75	124.08	0.60^*
	Ovary	219	152.42	1.43^*	462	362.68	1.27^*
	Endometrial	421	301.52	1.40^*	878	705.96	1.24^*
	Other female genital	33	37.45	0.88	80	88.47	0.90
	Bladder	125	113.19	1.10	287	273.89	1.05
	Kidney	71	85.30	0.83	170	191.37	0.89
	Renal/other urinary tract	9	14.51	0.62	33	36.66	0.90
	Brain	45	44.92	1.00	78	107.10	0.73^*
	Other sites	71	74.34	0.96	161	168.79	0.95
	Sub-total	1811	1699.50	1.07^*	4118	4063.64	1.01	1.01	(0.95–1.07)

All solid cancers (excluding contralateral breast)		2929	2621.98	1.12^*	6078	6223.02	0.98	1.11	(1.06–1.16)
Contralateral breast		2076	688.07	3.02^*	4415	1571.94	2.81^*	1.09	(1.04–1.15)

Abbreviations: CI=confidence interval; CNS=central nervous system; SIR=standardised incidence ratio=ratio of observed to expected cases.

Mean doses on the basis of tangential fields breast radiotherapy, see Table 1. ^*P<0.05.

RR=relative risk calculated using Poisson regression stratified by stage, age at treatment, year of treatment, chemotherapy and hormonal therapy.

Soft tissue histology: surgery+radiotherapy includes 16 angiosarcomas, 22 fibrosarcomas, 18 others and surgery only includes 2 angiosarcomas, 18 fibrosarcomas and 28 others.