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. 2009 Jan-Mar;12(1):3–11. doi: 10.4103/0972-2327.48845

Table 2.

Published studies using quantitative proteomic methods for identification of biomarkers in neurological disorders

Quantitative proteomics method Neurological diseases Features Tissues used Potential biomarkers Reference
2DE Huntington's disease. Combination of MALDI-TOF and LC-MS/MS platforms for biomarker discovery Plasma Clusterin, alpha 2 macroglobulin. Dalrymple et al.[45]
2D-DIGE Down syndrome Proteomic analysis of maternal serum Serum Alpha-1-acid, glycoprotein 1. Nagalla et al.[18]
2D- DIGE Guillain-Barré syndrome Differential proteomic profiling MALDI-TOF MS CSF Haptoglobin, Apolipoprotein A-IV. Yang et al.[55]
SDS-PAGE Multiple sclerosis Capillary liquid chromatography-electro spray-ion trap mass spectrometry. CSF CRTAC-IB, tetranectin. Hammack et al.[56]
2D-DIGE Traumatic brain injury of infancy Western blot confirmation of the identified biomarkers CSF Cystatin C, PGDS. Gao et al.[19]
2DE Alzheimer's Disease Differential proteomic profiling CSF Cathepsin-D, Apolipoprotein A-I. Castano et al.[57]
6-plex isobaric labeling Brain injury MALDI TOF/TOF and ESI-Q-TOF CSF GFAP, protein S100B, PARK7. Dayon et al.[58]
SDS-PAGE Multiple sclerosis Laser-capture micro dissection Brain Tissue factor, protein C inhibitor. Han et al.[59]
ICAT Alzheimer's disease LC-MS/MS CSF Amyloid precursor protein, Cathepsin B. Zang et al.[60]
Capillary isoelectric focusing Glioblastoma multiformae LC-MS/MS Brain cortex Wolf-Hirschhorn syndrome candidate 1. Li et al.[61]
2DE Systemic lupus erythematosus LC-MS/MS Serum Autoantigens for HSP90 Kimura et al.[62]
8-plex iTRAQ Alzheimer's disease SCX and LC-MS/MS CSF Clusterin, hemopoxin Choe et al.[32]
iTRAQ Traumatic brain injury LC-MS/MS Serum Serum amyloid A, C-reactive protein Hergenroeder et al.[21]
2DE Traumatic brain injury MALDI-TOF CSF Alpha 1 antitrypsin, haptoglobin 1 alpha 1. Conti et al.[47]