Table 1.
Peripheral blood stem cell mobilizing agents
| Agent class | Examples | Time of maximal mobilization |
|---|---|---|
| Chemotherapy | Cytoxan, 5-fluorouracil | 1–3 Weeks |
| Growth factors | G-CSF, GM-CSF, stem cell factor, thrombopoietin, erythropoietin, growth hormone, IL-3, IL-17, parathyroid hormone, VEGF, angiopoietin-1 | 4–6 Days |
| Antibodies | Anti-VLA-4, anti-VCAM-1 | 1–2 Days |
| Polyanions | Fucoidan, dextran sulfate | 1–2 h |
| Chemokines/chemokine mimetics | GROβ, KC (murine GRO), MIP1α, Met-SDF-1β, CTCE0021, CTCE0214 | 15min–2 h |
| Receptor antagonists/signaling pathway inhibitors | AMD3100, Rho GTPase inhibitor, β2-agonists | 1–6 h |
G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-3, interleukin-3; IL-17, interleukin-17; VCAM, vascular cell adhesion molecule-1; VEGF, vascular endothelial growth factor; VLA-4, very late antigen-4.