Figure 5.
Results of FiehnLib applications in SetupX/BinBase queries across nine studies (846 samples).
Upper panel: Unsupervised Principal Component Analysis graphs on 324 identified unique metabolites. For each species/organ combination, median normalized intensities were calculated including all metabolites that were positively detected in minimum 10% of all samples of a class. Mammalian samples are labeled in red, urine in yellow, E. coli in blue and plants and algae in green.
Lower panel: Venn diagram on a subset of 251 mammalian metabolites identified in plasma, urine and intestinal effluent metabolome. 36% of these metabolites were identified in all three body fluids such as inositol, alanine, palmitate, uric acid, creatinine, glucose and glycerol-alpha-phosphate. 37% of the compounds were only positively detected in two fluids, and 27% were unique for a specific fluid.