Figure 4.
MacroH2A1 binding positively correlates with heterochromatic chromatin marks and negatively correlates with active chromatin marks. (A) Volcano plot of Spearman's correlation coefficient for the macroH2A1 ChIP–chip data from IMR90 cells with each of 367 ChIP–chip data sets versus the corresponding significance score (−log2 P-value). (B) Average log2 ratios in macroH2A1-bound and unbound regions for the seven most positive correlations. (C) Same as in B for the seven most negative correlations.