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Nav channels are lost from the AIS following ischemic injury. A, B, After MCAO, contralateral (left) and ipsilateral (right) regions of rat cortex were immunolabeled for Nav channels (Pan-Nav, red), βIV spectrin (A, green) or ankG (B), and Hoechst to label nuclei (blue). The sections shown are from a brain collected 24 h after MCAO. Arrows indicate labeled AIS in layer 2/3 cortex. Scale bar, 50 μm.
