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. Author manuscript; available in PMC: 2009 Dec 17.
Published in final edited form as: Biometrics. 2009 Dec;65(4):1223–1232. doi: 10.1111/j.1541-0420.2009.01189.x

Table 2.

Simulated power × 100% to reject H0:VES = 0. Each table entry is based on applying the likelihood ratio test (LRT) to 10,000 simulated data sets generated assuming p = 0.2 transmission probability in the control arm, sample size m per arm, and maximum of 20 challenges per NHP. The LRTs were conducted assuming the correct vaccine mechanism of protection at the β = 0.1 significance level.

VES
Mechanism m 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9
Leaky 5 11 14 20 26 35 47 60 74 89 98
10 11 15 24 35 49 64 80 93 99 100
15 10 17 27 41 59 77 90 98 100 100
20 10 19 31 48 67 85 96 99 100 100
All-or-none 5 4 34 57 73 85 92 97 98 100 100
10 7 53 79 92 97 99 100 100 100 100
15 8 64 89 97 100 100 100 100 100 100
20 8 71 95 99 100 100 100 100 100 100