Table 3.
Results of MPXV iv challenge
| Monkey ID |
Group | Vaccine | Peak Lesion # | Blood viremia (genomes/ml)1 |
Throat swab viremia (genomes/ml)1 |
Disease | Day of Death |
|---|---|---|---|---|---|---|---|
| 4306 | 1 | pVEK 4pox | 8 | < | 569,000 | mild | Survived |
| 4307 | 1 | pVEK 4pox | 12 | < | 36,180 | mild | Survived |
| 4308 | 1 | pVEK 4pox | 10 | < | 1,837,500 | mild | Survived |
| 4309 | 1 | pVEK 4pox | 8 | < | 247,200 | mild | Survived |
| 4310 | 1 | pVEK 4pox | 0 | < | 8,770 | none | Survived |
| 4311 | 2 | pERK 4pox | 2 | < | 840,500 | mild | Survived |
| 4312 | 2 | pERK 4pox | 8 | < | 390,000 | mild | Survived |
| 4313 | 2 | pERK 4pox | 4 | < | 25,370 | mild | Survived |
| 4314 | 2 | pERK 4pox | 0 | < | 1,123,000 | none | Survived |
| 4315 | 2 | pERK 4pox | 12 | <6500 | 10,306,890 | mild | Survived |
| 4316 | 3 | pVEK flu HA |
TNTC† | 338,900 | 13,770,000 | grave | 9 |
| 4317 | 3 | pVEK flu HA |
105 | 1,044,990 | 25,360,000 | severe | Survived |
| 4318 | 3 | pVEK flu HA |
TNTC | 660,000 | 12,540,000 | severe | Survived |
| 4319 | 4 | pVEK flu HA |
TNTC† | 981,000 | 83,100,000 | grave | 9 |
| 4320 | 4 | pVEK flu HA |
TNTC† | 9,915,000 | 4,250,000 | grave | 12 |
| 4321 | 4 | pVEK flu HA |
TNTC | 5,160,000 | 3,351,000 | grave | 12 |
| 4322 | 5 | Dryvax | 0 | < | 84,800 | none | Survived |
| 4323 | 5 | Dryvax | 0 | < | 136,500 | none | Survived |
1
mean of two highest consecutive time points
†
moribund animal euthanized
na, not applicable
TNTC= Too numerous to count
< no genome detected (<5000 genomes/ml)