Table 2.
Interaction of specific receptors and other proteins with NC1 fragments of collagens IV, XV and XVIII
| Protein interactions | NC1 fragments |
|---|---|
| Receptors | |
| Integrins | |
| α1β1 and α2β1 | All NC1 (IV) fragments |
| Α5β1, αvβ5 and αvβ3 | Endostatin (Rehn et al., 2001) |
| α6β1 and αvβ3 | α3NC1(IV) or Tumstatin (Maeshima et al., 2000b) |
| α3β1 and αvβ3 | Canstatin (Kamphaus et al., 2000) |
| Glypican3 | Endostatin (Karumanchi et al., 2001) |
| VEGF-R2 | Endostatin (Kim et al., 2002) |
| ECM proteins | |
| Fibulin1, fibulin2, nidogen2 |
Endostatin and endostatin-like (Sasaki et al., 2000) |
| Perlecan, laminin1 | NC1(XV) and NC1(XVIII) (Sasaki et al., 2000) |
| MMP-2 | Endostatin (Kim et al., 2000; Lee et al., 2002) |
| Intracellular proteins | |
| Tropomyosin | Endostatin (MacDonald et al., 2001) |